Muse plays in Drop A Tuning in their song Liquid State. It has a metal feel to it with the muted, down-strum power chords, but most metal songs are slower. I like how the synth rolls alongside the guitar in the verses, it fills in the high range spectrum in the sound mix. Muse songs have a large sound to them - these songs are meant to fill giant arenas and are written with hooks that are meant to be chanted by large crowds of fans.
Personally, I'm not a huge fan of Drop A Tuning. I think it sounds sloppy, especially when it is mixed with heavy distortion and effects. If you want to play a guitar at such a low tuning, then why not buy a bass guitar? Mixers and engineers need to be careful when dealing with bands who play in Drop A, because chances are high that you'll be hearing a muddy mix (an unbalanced mix heavy in low notes) This problem can be fixed by boosting vocals in the mix, having guitar leads that utilize the higher end of the guitar neck, or adding synth riffs.